Estrumate allows for a more convenient and efficient AI (artificial insemination) program to control both breeding and calving intervals, as well as scheduling the entry of heifers into the milking herd by shortening cycle times through enhanced luteolysis to better fit certain management practices.
Estrumate allows for a more convenient and efficient AI (artificial insemination) program to control both breeding and calving intervals, as well as scheduling the entry of heifers into the milking herd by shortening cycle times through enhanced luteolysis to better fit certain management practices.
Estrumate (Cloprostenol Sodium) causes functional and morphological regression of the corpus luteum (luteolysis) in cattle. In normal, nonpregnant cycling animals, this effect on the life span of the corpus luteum usually results in estrus 2 to 5 days after treatment. In animals with prolonged luteal function (pyometra, mummified fetus, and luteal cysts), the induced luteolysis usually results in resolution of the condition and return to cyclicity. Pregnant animals may abort depending on the stage of gestation.
Estrumate is for Intramuscular use to induce luteolysis in beef and dairy cattle. The luteolytic action of Estrumate can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function.
| Directions | Two mL of Estrumate (500 mcg of cloprostenol) should be administered by INTRAMUSCULAR INJECTION for all indications in both beefand dairy cattle. Do not puncture stopper more than 12 times. RECOMMENDED USES:Unobserved or nondetected estrusCows which are not detected in estrus, although ovarian cyclicity continues, can be treated with Estrumate if a mature corpus luteum ispresent. Estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. Treated cattle should beinseminated at the usual time following detection of estrus. If estrous detection is not desirable or possible, treated animals may beinseminated twice at about 72 and 96 hours postinjection. Caution:Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Safety and Toxicity:At 50 and 100 times the recommended dose, mild side effects may be detected in some cattle. These include increased uneasiness, slightfrothing, and milk let-down. Contraindications:Estrumate should not be administered to a pregnant animal whose calf is not to be aborted. Precautions:There is no effect on fertility following the single or double dosage regimen when breeding occurs at induced estrus or at 72 and 96 hourspost treatment. Conception rates may be lower than expected in those fixed time breeding programs which omit the second insemination (ie,the insemination at or near 96 hours). This is especially true if a fixed time insemination is used following a single Estrumate injection. As with all parenteral products, careful aseptic techniques should be employed to decrease the possibility of post injection bacterial infection.Antibiotic therapy should be employed at the first sign of infection. Warnings:For veterinary use only. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution whenhandling this product. In the early stages, women may be unaware of their pregnancies. Estrumate is readily absorbed through the skin andmay cause abortion and/or bronchiospasms; direct contact with the skin should therefore be avoided. Accidental spillage on the skin shouldbe washed off immediately with soap and water Storage:
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